Melanostatin, a new melanin synthesis inhibitor. Production, isolation, chemical properties, structure and biological activity.
نویسندگان
چکیده
Melanostatin, a new antibiotic with melanin synthesis inhibitor activity, was isolated from the fermentation broth of Streptomyces clavifer No. N924-2. Its structure was determined by spectral analysis and degradation experiments. Melanostatin strongly inhibited melanin formation in Streptomyces bikiniensis NRRL B-1049 and B16 melanoma cells.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 44 1 شماره
صفحات -
تاریخ انتشار 1991